Background:
@EN Androgens stimulate the growth of hair in various area of skin including the pubis, axilla and beard, whereas in the scalp androgens promote beldness in genetically predisposed individuals.
Androgens bind to specific intracellular receptors, which modulate specific gene expression and so affect hair loss. Androgenetic baldness is first apparent on the frontal region, with recession of the hair line. As this progresses, alopecia also
develops on the vertex. But the posterior and lateral scalp area is spared, even in the most advanced cases, and even in old age.
@ES Objective:
@EN The purpose of our study is to find out the difference of androgen receptor expression in lesional and non lesional scalp of androgenetic alopecia patients by immunohistochemical staining.
@ES Methods:
@EN Biopsy specimens were taken from its lesion(vertex) and its non lesion(occiput) of 3 patients with androgenetic alopecia and 4 normal controls. The detection of androgen receptor was performed by an immunohistochemical technique(streptavidin
peroxidase method) using monoclonal antibody against androgen receptor.
@ES Results:
@EN Androgen receptors were strongly expressed in eccrine gland and sebaceous gland, and weakly expressed in epidermal cells, hair infundibulum, hair bulb epithelium and dermal hair papilla.
@ES Conclusion:
@EN There was no significant difference of the expression of androgen receptors in lesional and non lesional scalp of androgenetic alopecia. (Kor J Dermatol 1994 ; 32(5) : 8484~852)
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